L-Aspartyl-L-phenylalanine methyl ester
Aspartame
CAS: 22839-47-0;7421-84-3
Molecular Formula: C14H18N2O5
L-Aspartyl-L-phenylalanine methyl ester - Names and Identifiers
| Name | Aspartame |
| Synonyms | APM RP38 E962 c-mer Equal Aspartame Nutrasweet Asp-Phe-OMe L-ASP-PHE METHYL ESTER methyl alpha-aspartylphenylalaninate L-ASPARTYL-L-PHENYLALANINE METHYL ESTER L-Aspartyl-L-phenylalanine methyl ester methyl L-alpha-aspartyl-L-phenylalaninate L-alpha-aspartyl-L-phenylalanine-methylester Monoclonal Anti-MERTK antibody produced in mouse L-Phenylalanine, N-L-alpha-aspartyl-, 1-methyl ester |
| CAS | 22839-47-0 7421-84-3 |
| EINECS | 245-261-3 |
| InChI | InChI=1/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 |
| InChIKey | IAOZJIPTCAWIRG-QWRGUYRKSA-N |
L-Aspartyl-L-phenylalanine methyl ester - Physico-chemical Properties
| Molecular Formula | C14H18N2O5 |
| Molar Mass | 294.31 |
| Density | 1.2051 (rough estimate) |
| Melting Point | 242-248°C |
| Boling Point | 436.08°C (rough estimate) |
| Specific Rotation(α) | 15.5 º (c=4, 15N formic acid) |
| Flash Point | 277.8°C |
| Water Solubility | Soluble in formic acid, dimethyl sulfoxide. Sparingly soluble in water and ethanol. |
| Solubility | Slightly soluble in water (about 1%) and ethanol (0.26mg/100ml). |
| Vapor Presure | 2.6E-12mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White |
| Odor | odorless with a sweet taste |
| Merck | 14,839 |
| BRN | 2223850 |
| pKa | pKa 3.19±0.01 (H2O t=25.0 I=0.100(NaCl))(Approximate);7.87±0.02(H2O t=25.0 I=0.100(NaCl))(Approximat |
| PH | pH(8g/l, 25℃) : 4.5～6.0 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 14.5 ° (C=4, 15mol/L |
| MDL | MFCD00002724 |
| Physical and Chemical Properties | The trait has obvious sweet taste, and its sweetness is 170 times that of sucrose. After a lot of structural modification work, many promising and sweet peptide derivatives were synthesized, so sweet peptides are also the general name of peptide sweeteners |
| Use | Used as a food additive, high-intensity nutritive sweetener |
L-Aspartyl-L-phenylalanine methyl ester - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | WM3407000 |
| TSCA | Yes |
| HS Code | 29242990 |
| Toxicity | TDLo orl-wmn: 3710 mg/kg:SKN AIMEAS 104,207,86 |
L-Aspartyl-L-phenylalanine methyl ester - Upstream Downstream Industry
| Raw Materials | L-Phenylalanine L(+)-Aspartic acid |
L-Aspartyl-L-phenylalanine methyl ester - Reference
| Reference Show more | 1. Li Pan, Zhang Dingkun, Lin Junzhi, et al. Based on the description of time advantage combined with multivariate statistical analysis, the optimal mode of the prescription of traditional Chinese medicine buccal tablets is constructed: taking compound Caohualuan buccal tablets as an example [J]. Chinese Journal of Traditional Chinese Medicine, 2019(14). 2. Kang Zhijiao, Xia Yanbin, Zhao Zhiyou, determination of aspartame in betel nut by high performance liquid chromatography [J]. Journal of Food Safety and Quality Inspection, 2017(05):1857-1861. 3. Lin Junzhi, Li Pan, Qiu Min, Ke Xiumei, Han Li, Yang Ming, Wu Zhenfeng, Zhang Dingkun. Study on the Suitability of Amphiphilic Block Copolymer for Bitter Suppression of Decoction Based on Intestinal Flora [J]. Chinese herbal medicine, 2021,52(01):65-74.[4] Chen Wenjuan. Design and Experimental Study of Breast Cancer Vaccine Based on Polymer Carrier [D]. Peking Union Medical College, 2020.[5] Wang Ying. Based on intestinal microenvironment to explore the difference of immunomodulatory effects between Lonicera japonica and Lonicera japonica polysaccharide [D]. Beijing university of traditional Chinese medicine, 2020. 4. Yin, Kai-Jing, et al. "Effects of different sweeteners on behavior and neurotransmitters release in mice." Journal of food science and technology 57.1 (2020): 113-121.https:// doi.org/10.1007/s13197-019-04036-6 |
L-Aspartyl-L-phenylalanine methyl ester - Nature
Open Data Verified Data
white crystalline powder, odorless, strong sweet taste, pure sweet taste, sweetness of sucrose 100~200 times. Unstable in aqueous solution, easy to decompose and lose the sweet taste, stable under dry conditions or Ph 2~5 range.
Last Update：2024-01-02 23:10:35
L-Aspartyl-L-phenylalanine methyl ester - Preparation Method
Open Data Verified Data
with aspartic acid and phenylalanine as raw materials, through amino protection, anhydride, condensation, hydrolysis, neutralization and other steps of synthesis.
Last Update：2022-01-01 10:10:09
L-Aspartyl-L-phenylalanine methyl ester - Standard
Authoritative Data Verified Data
This product is N -L -a-aspartyl-L-phenylalanine -1-methyl ester. Calculated as the dried product, including C14H18N2C)5 should be 98.0% ~ 102.
Last Update：2024-01-02 23:10:35
L-Aspartyl-L-phenylalanine methyl ester - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Sweet.
- This product is very slightly soluble in water, insoluble in ethanol, n-hexane or dichloromethane.
specific rotation
take this product, precision weighing, add 1 5M o l/L formic acid solution to dissolve and quantitatively dilute to make a solution containing about 40mg per lm l, immediately determined according to law (General Rule 0 6 2 1 ) , specific rotation is 14. 5 ° to 16.5 °.
Last Update：2022-01-01 11:22:54
L-Aspartyl-L-phenylalanine methyl ester - Introduction
Slightly soluble in water (about 1%) and ethanol (0-26mg/100ml). It is odorless and has a strong sweet taste. The sweetness of its dilute solution is about 100-200 times that of sucrose. Its sweet taste is very similar to granulated sugar, and it has a cool feeling. The pH value of 0-8% aqueous solution is 4-6-5. It is unstable in aqueous solution, easy to decompose and lose sweetness, and is more stable at low temperature and pH 3-5.
Last Update：2022-10-16 17:15:05
L-Aspartyl-L-phenylalanine methyl ester - Use
Open Data Verified Data
Aspartame is a protein-based non-sugar sweetener with a sweetness of 170 times that of sucrose. Often used in combination with sucrose or other sweeteners. Can be used for all kinds of food, according to the production needs of appropriate use, the general dosage of 0. 5g/kg.
Last Update：2022-01-01 10:10:09
L-Aspartyl-L-phenylalanine methyl ester - Differential diagnosis
Authoritative Data Verified Data
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 768) (General 0402).
Last Update：2022-01-01 11:22:54
L-Aspartyl-L-phenylalanine methyl ester - Exam
Authoritative Data Verified Data
absorbance
take this product, precision weighing, dissolving and quantitatively diluting with 2M o l/L hydrochloric acid solution to make a solution containing 10 mg per lm l, UV-visible spectrophotometry (General rule 0401), measured at the wavelength of 430mn absorbance, should not be greater than 0.022.
acidity
take l .O g of this product, add water, dissolve 25ml, and then determine it according to law (General rule 0631). The pH value should be 4 .0~6 .0.
Related substances
take this product, dissolve it with mobile phase and make a solution containing 6mg per lm l as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, the mobile phase was diluted to the scale, and the solution was used as a control solution. Determined by high performance liquid chromatography (General 0512). Silica gel was bonded with eighteen alkyl silanes as a filler (KR masil C18 250mm x 4. 6mm sum column is applicable); With citrate buffer (take 9 .6g citric acid, dissolved in about 800mi water, with lm o l/L sodium hydroxide solution to adjust the p H value to 4. 7, add water to 1000ml) -methanol (67 : 33) as mobile phase; Detection wavelength is 254nm, take L-aspartyl-L-phenylalanine and phenylalanine appropriate amount, precision weighing, add the mobile phase to dissolve and dilute to make a mixed solution containing 15 K in each lm l, Take 2(^ 1, inject human liquid chromatograph, the resolution of L-aspartyl-L-phenylpropoxy acid peak and phenylalanine peak should meet the requirements. The sample solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If the impurity peak is shown in the chromatogram of the test solution, the sum of the peak areas of each impurity shall not be greater than the main peak area (2.0%) of the control solution.
loss on drying
take this product at 105T: dry for 4 hours, weight loss shall not be over 0831 (general rule).
ignition residue
The l .O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product 0.67g, add calcium hydroxide l .O g, mix, add water 2 m l, stir evenly, dry at 40-C, slowly burn to charring, then burn at 500-600°C to Ash completely, cool, add hydrochloric acid 8M l and water 23ML, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0.0003%).
Last Update：2022-01-01 11:22:55
L-Aspartyl-L-phenylalanine methyl ester - Content determination
Authoritative Data Verified Data
take this product about 0.25g, precision weighing, add formic acid 3ml and glacial acetic acid 50ml, dissolve, according to the potential titration method (General rule 0701), titrate with high gas acid titration solution (0.1mol/L), and the results of the titration with blank test correction. Each 1 ml of perchloric acid titration solution (0.1 Mo/L) corresponds to 29.43 mg of C. H18N2Q.
Last Update：2022-01-01 11:22:56
L-Aspartyl-L-phenylalanine methyl ester - Category
Authoritative Data Verified Data
pharmaceutical excipients, sweeteners and flavoring agents.
Last Update：2022-01-01 11:22:56
L-Aspartyl-L-phenylalanine methyl ester - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:22:56
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Product Name: Aspartame Request for quotationCAS: 22839-47-0
Tel: +86-17551318830
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Product Name: Aspartame Request for quotationCAS: 22839-47-0/7421-84-3
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Mobile: +86-17551318830
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Product Name: Aspartame Request for quotation
CAS: 22839-47-0
Tel: 0086-551-65418684
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info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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CAS: 22839-47-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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Product List: View Catalog
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Product Name: Aspartame Request for quotationCAS: 22839-47-0;7421-84-3
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
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Wechat: 18627766980
Multiple SpecificationsSpot supply
Product Name: Aspartame Visit Supplier Webpage Request for quotationCAS: 22839-47-0
Tel: 18301782025
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Mobile: 18021002903
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Product Name: aspartame Request for quotation
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QQ: 609149175Send QQ message
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Raw Materials for L-Aspartyl-L-phenylalanine methyl ester